The Annals the journal of Pharmacy Technology
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Drug Intelligence & Clinical Pharmacy: Vol. 15, No. 5, pp. 325-330.
© 1981 Harvey Whitney Books Company.
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Research Articles

Trimethoprim: clinical use and pharmacokinetics

WT Friesen, YA Hekster, and TB Vree

The recent marketing of trimethoprim (TMP) as a single drug has resulted in interest in the use of this drug to treat common infections. The history and antibacterial properties of TMP are reviewed. Indications for the clinical use of TMP are presented, and possible new uses for the drug are considered. The significance of adverse effects is discussed. The pharmacokinetic properties of TMP are reviewed with particular emphasis on the renal handling of the drug and its advantages over TMP/sulfonamide combinations in relation to renal function and toxicity.




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Copyright © 1981 by Harvey Whitney Books Company.