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Drug Intelligence & Clinical Pharmacy: Vol. 17, No. 12, pp. 904-905.
© 1983 Harvey Whitney Books Company.
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Research Articles

Cimetidine's effect on steady-state serum nortriptyline concentrations

DD Miller, JB Sawyer, and JP Duffy

A cimetidine-nortriptyline interaction in a 52-year-old black male is reported. After concomitant administration of cimetidine and nortriptyline for two weeks, steady-state nortriptyline concentrations fell 42 percent when cimetidine was discontinued. Later, during rechallenge with cimetidine, serum nortriptyline concentrations increased significantly, but subsequently fell again when cimetidine was discontinued. The possible clinical consequences of this interaction are discussed.


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 Drug Metab. Dispos.Home page
M. Madeira, M. Levine, T. K. H. Chang, A. Mirfazaelian, and G. D. Bellward
The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6.
Drug Metab. Dispos., April 1, 2004; 32(4): 460 - 467.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by Harvey Whitney Books Company.