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Drug Intelligence & Clinical Pharmacy: Vol. 17, No. 7, pp. 549-550.
© 1983 Harvey Whitney Books Company.
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Research Articles

Hypoprothrombinemia in naproxen overdose

PK Waugh and DW Keatinge

Transient prolongation of the prothrombin time was observed in the setting of a 10-g overdose of naproxen. The patient reported was previously healthy, without chronic liver disease, bleeding disorders, or malnutrition. The most likely mechanism for this effect is direct inhibition of the synthesis of vitamin-K-dependent clotting factors, possibly via production of "abnormal" prothrombin.




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Copyright © 1983 by Harvey Whitney Books Company.