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Drug Intelligence & Clinical Pharmacy: Vol. 18, No. 12, pp. 980-981.
© 1984 Harvey Whitney Books Company.
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Research Articles

Prolonged hypnotic response to triazolam-cimetidine combination in an elderly patient

WA Parker and RA MacLachlan

An 82-year-old white female developed a 36-hour episode of unresponsiveness/drowsiness after a single dose of triazolam 0.5 mg in combination with cimetidine. This case illustrates the need for careful dose-titration of drug therapy in the elderly, particularly when a drug with the potential to impair drug metabolism is coadministered. Cimetidine, when coadministered with triazolam, may increase the intensity and duration of action of single doses of triazolam.




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Copyright © 1984 by Harvey Whitney Books Company.