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Drug Intelligence & Clinical Pharmacy: Vol. 18, No. 4, pp. 314-316.
© 1984 Harvey Whitney Books Company.
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Research Articles

Hypoprothrombinemia associated with cefoperazone treatment

P Cristiano

A patient with acute renal failure and gram-negative septicemia developed hypoprothrombinemia during treatment with cefoperazone. The coagulation defect was corrected by vitamin K administration. A multifactorial pathogenetic mechanism of vitamin K deficiency that developed during treatment with parenteral antibiotics is presented.


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Copyright © 1984 by Harvey Whitney Books Company.