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Research Articles |
Thirty-six patients suffering from severe pain due to bone involvement from cancer participated in an analgesic study that compared single doses of ketoprofen 100 or 400 mg iv or injectable acetylsalicylic acid 1 g. A double-blind, balanced incomplete block design was adopted, in which each patient received two of the three test treatments, with an interval of 24 hours. Ketoprofen 400 mg proved significantly superior to 100 mg of the same drug, and was superior to 1 g of the acetylsalicylic acid derivative in the patients' assessment of the overall response. This was expressed by a visual analog scale and preferences. No adverse reaction was observed with any treatment.
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  E. McNicol, S. Strassels, L. Goudas, J. Lau, and D. Carr Nonsteroidal Anti-Inflammatory Drugs, Alone or Combined With Opioids, for Cancer Pain: A Systematic Review J. Clin. Oncol., May 15, 2004; 22(10): 1975 - 1992. [Abstract] [Full Text] [PDF]
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 C. A Jenkins and E. Bruera Nonsteroidal anti-inflammatory drugs as adjuvant analgesics in cancer patients Palliative Medicine, April 1, 1999; 13(3): 183 - 196. [Abstract] [PDF]
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