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Drug Intelligence & Clinical Pharmacy: Vol. 18, No. 6, pp. 483-486.
© 1984 Harvey Whitney Books Company.
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Research Articles

Phenytoin-isoniazid interaction: a kinetic approach to management

DR Witmer and WA Ritschel

A case of phenytoin-isoniazid drug interaction is reported. Pharmacokinetic evaluation was performed on the basis of two different phenytoin serum concentrations obtained on two different dosage regimens. Whereas Vmax was found to be in the normal range, the patient's Km was increased five-fold. The literature regarding this interaction is reviewed. This case illustrates the usefulness of pharmacokinetic methods in the management of phenytoin-isoniazid interaction.




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Copyright © 1984 by Harvey Whitney Books Company.