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Drug Intelligence & Clinical Pharmacy: Vol. 18, No. 9, pp. 716-720.
© 1984 Harvey Whitney Books Company.
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Research Articles

Fatal maprotiline intoxication

RA Curtis, N Giacona, D Burrows, JL Bauman, and M Schaffer

We report a fatal case of drug toxicity associated with torsade de pointes following an overdose of the tetracyclic antidepressant, maprotiline (Ludiomil). Tissue and plasma levels were obtained at autopsy and are noted. In addition, the cardiovascular effects, pharmacokinetics, and toxicity of maprotiline are reviewed and compared with that of tricyclic antidepressants.


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PsychosomaticsHome page
W. V. R. Vieweg and M. A. Wood
Tricyclic Antidepressants, QT Interval Prolongation, and Torsade de Pointes
Psychosomatics, October 1, 2004; 45(5): 371 - 377.
[Abstract] [Full Text] [PDF]




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