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Research Articles |
A piroxicam-warfarin interaction is presented with a discussion of the possible mechanism of action. A 60-year-old white male on warfarin therapy for recurrent pulmonary embolism and deep venous thrombophlebitis showed a decrease in his previously therapeutic and stable prothrombin time when piroxicam was discontinued from his drug regimen. On two rechallenges over a ten-month period, his prothrombin times showed consistent and clinically significant fluctuations as piroxicam was added and deleted from his drug regimen.
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  F. Dentali, J. D Douketis, K. Woods, L. Thabane, G. Foster, A. Holbrook, and M. Crowther Does Celecoxib Potentiate the Anticoagulant Effect of Warfarin? A Randomized, Double-Blind, Controlled Trial Ann. Pharmacother., July 1, 2006; 40(7): 1241 - 1247. [Abstract] [Full Text] [PDF]
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 A. M. Holbrook, J. A. Pereira, R. Labiris, H. McDonald, J. D. Douketis, M. Crowther, and P. S. Wells Systematic Overview of Warfarin and Its Drug and Food Interactions Arch Intern Med, May 23, 2005; 165(10): 1095 - 1106. [Abstract] [Full Text] [PDF]
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