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Research Articles |
Vancomycin is an effective and widely used antistaphylococcal antibiotic. Despite several decades of use, however, our knowledge of the toxicologic and pharmacokinetic properties of vancomycin remains incomplete. This review summarizes current information regarding the adverse reactions and pharmacokinetics of vancomycin. Although there have been reports of side effects with vancomycin, these effects tend to be infrequent, easily managed, and reversible. Several methods for adjustment of vancomycin therapy have been recommended. The relationship between serum concentrations of vancomycin and the occurrence of ototoxicity or nephrotoxicity has not been well established. However, because of large interpatient variations in pharmacokinetic parameters, it seems preferable to individualize vancomycin therapy based on serum concentration data.
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  M. Rybak, B. Lomaestro, J. C. Rotschafer, R. Moellering Jr., W. Craig, M. Billeter, J. R. Dalovisio, and D. P. Levine Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists Am. J. Health Syst. Pharm., January 1, 2009; 66(1): 82 - 98. [Full Text] [PDF]
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 D. S. Buelga, M. del Mar Fernandez de Gatta, E. V. Herrera, A. Dominguez-Gil, and M. J. Garcia Population Pharmacokinetic Analysis of Vancomycin in Patients with Hematological Malignancies Antimicrob. Agents Chemother., December 1, 2005; 49(12): 4934 - 4941. [Abstract] [Full Text] [PDF]
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