The Annals
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Drug Intelligence & Clinical Pharmacy: Vol. 20, No. 10, pp. 783-785.
© 1986 Harvey Whitney Books Company.
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Research Articles

Vancomycin-induced neutropenia during treatment of osteomyelitis in an outpatient

K Henry, I Steinberg, and KB Crossley

A case of vancomycin-associated neutropenia occurring during long-term outpatient therapy with vancomycin is described. Pharmacokinetic studies demonstrated that the patient's vancomycin serum levels were within an acceptable range during treatment. Eighteen other reported cases of vancomycin-associated leukopenia are discussed in brief. An immunologic mechanism has been proposed but a clear understanding is lacking. Patients receiving long-term vancomycin therapy should have their white blood cell counts periodically monitored.


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Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists
Am. J. Health Syst. Pharm., January 1, 2009; 66(1): 82 - 98.
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M. Segarra-Newnham and S. S Tagoff
Probable Vancomycin-Induced Neutropenia
Ann. Pharmacother., November 1, 2004; 38(11): 1855 - 1859.
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Copyright © 1986 by Harvey Whitney Books Company.