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Drug Intelligence & Clinical Pharmacy: Vol. 20, No. 3, pp. 223-224.
© 1986 Harvey Whitney Books Company.
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Research Articles

Moxalactam myoclonus, seizures, and encephalopathy

I Cho, JM Bertoni, and L Hopkins

Severe myoclonus, generalized seizures, and marked stupor occurred in a 39-year-old woman with chronic renal insufficiency after one week of moxalactam 2 g iv q8h. Moxalactam serum levels far exceeded the recommended therapeutic range. The drug half-life was 17 hours (normal 1.9). Excessively high levels of moxalactam, which penetrates the blood-brain-barrier relatively easily, may provoke seizures and encephalopathy.





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Copyright © 1986 by Harvey Whitney Books Company.