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Drug Intelligence & Clinical Pharmacy: Vol. 20, No. 4, pp. 281-283.
© 1986 Harvey Whitney Books Company.
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Research Articles

Cefoperazone-induced coagulopathy

Freedy HR Jr, AB Cetnarowski, RM Lumish, and FJ Schafer

A number of recent articles have reviewed the problem of hypoprothrombinemia and bleeding associated with antibiotic therapy. We report three cases in which bleeding is believed to be related to a prolonged prothrombin time secondary to cefoperazone therapy. Reports of coagulopathies such as these are increasing in number and call attention to the need to monitor the prothrombin time during cefoperazone therapy.


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J. T. Mader, J. Wang, and J. H. Calhoun
Antibiotic Therapy for Musculoskeletal Infections
J. Bone Joint Surg. Am., December 1, 2001; 83(12): 1878 - 1890.
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Copyright © 1986 by Harvey Whitney Books Company.