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Research Articles |
Cimetidine is one of the most frequently prescribed drugs with a known potential to interfere with the metabolic disposition of numerous other medications. Some of these drug interactions may be hazardous to patients. The hepatic and renal mechanisms of drug interactions with cimetidine are discussed in this article. The interactive processes include inhibition of hepatic microsomal enzyme activity, reduction of liver blood flow, and competition for renal tubular secretory sites. The clinical significance and proposed mechanisms of interaction for individual drugs are also presented.
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  J. Manlucu, M. Tonelli, J. G. Ray, A. Papaioannou, G. Youssef, H. R. Thiessen-Philbrook, A. Holbrook, and A. X. Garg Dose-reducing H2 receptor antagonists in the presence of low glomerular filtration rate: a systematic review of the evidence Nephrol. Dial. Transplant., November 1, 2005; 20(11): 2376 - 2384. [Abstract] [Full Text] [PDF]
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 E. J. Drea Transition of Products From Prescription to Over the Counter: The H2 Antagonists Journal of Pharmacy Practice, January 1, 1992; 5(1): 22 - 30. [Abstract] [PDF]
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