Precautions in the use of Michaelis-Menten kinetics in the prediction of phenytoin levels
T Jochsberger
The Michaelis-Menten equation is one of the various techniques available for predicting steady-state plasma levels of phenytoin. In actual practice, however, data are not always available or reliable. This case report emphasizes the importance of establishing the quality of the data and determining that steady state has been achieved. The addition of a third point to the graph used to estimate parameters greatly increases prediction accuracy.
