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Drug Intelligence & Clinical Pharmacy: Vol. 21, No. 3, pp. 267-272.
© 1987 Harvey Whitney Books Company.
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Research Articles

Effect of thioridazine on phenytoin serum concentration: a retrospective study

CD Sands, JD Robinson, RB Salem, RB Stewart, and C Muniz

Serum phenytoin concentrations before and after the addition of thioridazine were retrospectively compared in 27 adults to determine if an interaction occurred between these two drugs. A change in the serum phenytoin concentration of +/- 4 micrograms/ml was considered clinically significant; by this definition four patients (14.8 percent) had an increase, two (7.4 percent) had a decrease, and most (77.8 percent) demonstrated no change. The mean difference was 0.8 microgram/ml +/- 3.7 micrograms/ml and was not found to be statistically significant (p less than 0.1). Clinically important alterations in phenytoin serum concentration as caused by thioridazine appear to be infrequent.




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Copyright © 1987 by Harvey Whitney Books Company.