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Drug Intelligence & Clinical Pharmacy: Vol. 21, No. 4, pp. 355-358.
© 1987 Harvey Whitney Books Company.
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Research Articles

Efficacy of adjunctive carbamazepine in the treatment of chronic schizophrenia

JM Herrera, JJ Sramek, and JF Costa

Six treatment-resistant schizophrenic patients were given a ten-week single-blind trial of carbamazepine. Treatment resistance was determined on the basis of documented failure to respond to treatment with at least three neuroleptic drugs from two different chemical classes. The adjunctive use of carbamazepine resulted in a significant improvement of the negative symptoms of schizophrenia. These symptoms are often poorly responsive to conventional antipsychotic drugs. Therefore, controlled studies should be performed to further assess the possible efficacy of carbamazepine in schizophrenia.


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Home page
 Arch Gen PsychiatryHome page
W. T. Carpenter Jr, R. Kurz, B. Kirkpatrick, T. E. Hanlon, A. T. Summerfelt, R. W. Buchanan, R. W. Waltrip, and A. Breier
Carbamazepine Maintenance Treatment in Outpatient Schizophrenics
Arch Gen Psychiatry, January 1, 1991; 48(1): 69 - 72.
[Abstract] [PDF]


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Copyright © 1987 by Harvey Whitney Books Company.