 |
 |
 |
 |
 |
 |
 |
|
|
|
|||||||||
|
|||||||||||
Research Articles |
Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Poisindex, a widely used poisoning treatment resource, recommends dosing pralidoxime chloride as an intermittent iv infusion every 8-12 hours, whereas other authors have used continuous iv infusion with good results. Available animal data suggest that a serum concentration of 4 micrograms/ml may be a minimal level to protect against the toxic effects of organophosphates. Pharmacokinetic simulations, based on parameters obtained from healthy nonpoisoned subjects, show that pralidoxime levels fall rapidly to less than 4 micrograms/ml within 1.5-2 hours after a 1-g iv bolus. Continuous iv infusion (0.5 g/h) maintains pralidoxime levels greater than 4 micrograms/ml throughout the length of infusion. We conclude that continuous iv infusion of pralidoxime chloride may be the preferred method of administration in patients with acute organophosphate poisoning. Clinical trials will be necessary to document the effectiveness of this regimen.
This article has been cited by other articles:
|
|
 |
|
  S. W. Wiener and R. S. Hoffman Nerve Agents: A Comprehensive Review J Intensive Care Med, January 1, 2004; 19(1): 22 - 37. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Eddleston, L. Szinicz, P. Eyer, and N. Buckley Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials QJM, May 1, 2002; 95(5): 275 - 283. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
 |
 |
 |
 |
