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Research Articles |
A patient with acquired immunodeficiency syndrome (AIDS) developed rash, fever, neutropenia, and elevated liver function tests during an initial course of trimethoprim-sulfamethoxazole (TMP-SMX) therapy. Upon reexposure to the drug, the patient experienced a severe anaphylactoid reaction associated with pulmonary edema and rhabdomyolysis. Reactions associated with TMP-SMX rechallenge in this patient population have been previously reported but have not been associated with this degree of severity. TMP-SMX therapy should be instituted with extreme caution in patients with AIDS who have demonstrated a prior hypersensitivity reaction to the drug.
This article has been cited by other articles:
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  C. M. Sass Trimethoprim-Sulfamethoxazole Induced Neutropenia and Dermatologic Reactions in Patients With Acquired Immunodeficiency Syndrome Journal of Pharmacy Practice, January 1, 1992; 5(6): ix - x. [PDF]
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