The Annals New | Pharmaco Epidemiology and Therapeutic Risk Management
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     

Drug Intelligence & Clinical Pharmacy: Vol. 22, No. 10, pp. 769-772.
© 1988 Harvey Whitney Books Company.
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cleary, J.
Right arrow Articles by Fletcher, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cleary, J.
Right arrow Articles by Fletcher, C.

Research Articles

Effect of infusion rate on amphotericin B-associated febrile reactions

JD Cleary, D Weisdorf, and CV Fletcher

Our objective was to prospectively study febrile and chill reactions associated with two amphotericin B (AB) infusion rates, slow (2-hour) versus rapid (45 minute). Seventeen consenting bone marrow transplant recipients in whom AB was to be initiated for documented or suspected fungal infections were recruited. After standardized premedication, patients received eight daily AB infusions (0.5 mg/kg/d, concentration 0.25 mg/ml). Rate was assigned using a randomized, crossover pair design. Axillary temperature, chills, and meperidine dose required to resolve chills were monitored for each infusion. For the first pair of infusions, fever (defined as a rise of 1 degree C) occurred frequently, in 12 of 17 (70.5 percent) and 13 of 17 patients (76.4 percent), with a mean rise of 1.7 degrees C (range 1.1-3.7) and 1.7 degrees C (1.1-3.5) degrees for the 45-minute and 2-hour infusions, respectively (p greater than 0.10). Chills were observed in 15 of 17 (88.2 percent) and 14 of 17 (82.3 percent) recipients of the 45-minute and 2-hour infusions, respectively. The time of onset (p greater than 0.10) and the duration of chills (p = 0.08) were similar for both infusion rates. Meperidine requirements for rapid and slow infusions were similar as well (p = 0.12). These data suggest that for patients free of preexisting renal and cardiac disease, rapid AB infusions are well tolerated and produce adverse reactions (fever and chills) similar in nature and severity to slower infusions.


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
M. Simitsopoulou, E. Roilides, J. Dotis, M. Dalakiouridou, F. Dudkova, E. Andreadou, and T. J. Walsh
Differential Expression of Cytokines and Chemokines in Human Monocytes Induced by Lipid Formulations of Amphotericin B
Antimicrob. Agents Chemother., April 1, 2005; 49(4): 1397 - 1403.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Sau, S. S. Mambula, E. Latz, P. Henneke, D. T. Golenbock, and S. M. Levitz
The Antifungal Drug Amphotericin B Promotes Inflammatory Cytokine Release by a Toll-like Receptor- and CD14-dependent Mechanism
J. Biol. Chem., September 26, 2003; 278(39): 37561 - 37568.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
C. R. Marchbanks and K. A. Rowley
Update on Infections in the Immunocompromised Host
Journal of Pharmacy Practice, January 1, 1991; 4(5): 282 - 294.
[Abstract] [PDF]


homecopy help contact us subscription past issues search current issue
Copyright © 1988 by Harvey Whitney Books Company.