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Drug Intelligence & Clinical Pharmacy: Vol. 22, No. 5, pp. 373-380.
© 1988 Harvey Whitney Books Company.
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Research Articles

Neuroleptic plasma concentrations and clinical response: in search of a therapeutic window

JJ Sramek, SG Potkin, and R Hahn

There is much interest in finding a therapeutic window for commonly used neuroleptics so that dosage can be individualized and side effects minimized. The authors review specific requirements of good study design and survey the literature that has investigated the relationship between therapeutic response and plasma concentrations of neuroleptics. The evidence from a number of fixed-dose haloperidol studies suggests, but does not yet prove, the existence of a therapeutic window for this compound.


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Home page
 Journal of Pharmacy PracticeHome page
J. S. Markowitz and K. S. Patrick
Plasma Antipsychotic Drug Concentrations: Practical Clinical Considerations
Journal of Pharmacy Practice, April 1, 1996; 9(2): 130 - 132.
[Abstract] [PDF]


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Copyright © 1988 by Harvey Whitney Books Company.