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Research Articles |
A rare complication of nonsteroidal antiinflammatory drug (NSAID) use, particularly in patients with collagen vascular or autoimmune diseases, is aseptic meningitis. A healthy 21-year-old man receiving naproxen for muscle spasm was admitted with a chief complaint of severe headache. Approximately one week after beginning naproxen, the patient developed headache, fever (T 38.8 degrees C), shaking chills, and nuchal rigidity with occasional nausea and vomiting resulting in a 15-lb weight loss. Findings from a cerebrospinal fluid examination revealed polymorphonuclear pleocytosis and elevated protein, but no evidence of infection with bacteria, fungi, mycobacteria, or viral agents was noted. Within 36 hours of discontinuing naproxen, the meningitis-like symptoms markedly improved. Rechallenge with naproxen was not performed. In patients exhibiting meningitis-like symptoms, a thorough drug history, including that of recent or intermittent NSAID use, should be obtained.
This article has been cited by other articles:
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  R. A. Bonnel, M. L. Villalba, C. B. Karwoski, and J. Beitz Aseptic Meningitis Associated With Rofecoxib Arch Intern Med, March 25, 2002; 162(6): 713 - 715. [Abstract] [Full Text] [PDF]
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G. Moris and J. C. Garcia-Monco The Challenge of Drug-Induced Aseptic Meningitis Arch Intern Med, June 14, 1999; 159(11): 1185 - 1194. [Abstract] [Full Text] [PDF]
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