 |
 |
 |
 |
 |
 |
 |
|
|
|
|||||||||
|
|||||||||||
Research Articles |
A 72-year-old man had been taking warfarin for a pulmonary embolus and recurrent deep-vein thromboses. His prothrombin times (PTs) were maintained between 15 and 18 sec (PT ratio 1.25-1.5 x control) for several months on a dose of warfarin 2.5 mg/d. Six weeks prior to starting ciprofloxacin 500 mg bid, the patient's PT was 15.5 sec (Pt ratio 1.29 x control). After one week of ciprofloxacin, his PT had increased to 22 sec (PT ratio 1.83 x control). No other causes for the increase were apparent. It is recommended that patients receiving both medications have their prothrombin times carefully monitored and warfarin doses adjusted only as necessary.
This article has been cited by other articles:
|
|
 |
|
  D. N Carroll and D. G Carroll Interactions Between Warfarin and Three Commonly Prescribed Fluoroquinolones Ann. Pharmacother., May 1, 2008; 42(5): 680 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Washington, S. Y. E. Hou, N. C. Hughes, C. Campanella, and B. Berner Ciprofloxacin Prolonged-Release Tablets Do Not Affect Warfarin Pharmacokinetics and Pharmacodynamics J. Clin. Pharmacol., October 1, 2007; 47(10): 1320 - 1326. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
 |
 |
 |
 |
