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Research Articles |
The increased frequency and duration of antifungal treatment with amphotericin B in immunocompromised patients has stimulated a great deal of research into the mechanisms of its nephrotoxic effects and treatment modalities designed to attenuate these effects. A review of amphotericin B-induced nephrotoxicity, the underlying pathophysiologic mechanisms, and the role of salt loading as a means of minimizing renal impairment are described. Both animal and human studies regarding the efficacy of sodium loading are presented as well as a case report describing the use of salt supplementation over a prolonged course of therapy.
This article has been cited by other articles:
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  B. Holler, S. A. Omar, M. D. Farid, and M. J. Patterson Effects of Fluid and Electrolyte Management on Amphotericin B-Induced Nephrotoxicity Among Extremely Low Birth Weight Infants Pediatrics, June 1, 2004; 113(6): e608 - e616. [Abstract] [Full Text]
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 C. R. Marchbanks and K. A. Rowley Update on Infections in the Immunocompromised Host Journal of Pharmacy Practice, January 1, 1991; 4(5): 282 - 294. [Abstract] [PDF]
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