The Annals
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DICP, The Annals of Pharmacotherapy: Vol. 24, No. 12, pp. 1175-1176.
© 1990 Harvey Whitney Books Company.
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Research Articles

Massive hepatic enlargement with fatty change associated with ketoconazole

JD Gradon and DV Sepkowitz

Several forms of hepatic toxicity have been described with the antifungal agent ketoconazole. We report a case of massive liver enlargement with fatty infiltration presenting as gastric compression. This occurred in a young woman with AIDS taking ketoconazole as maintenance therapy for cryptococcal meningitis. This is the first reported case of ketoconazole causing fatty change in the liver.




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Copyright © 1990 by Harvey Whitney Books Company.