Potential neurologic toxicity related to ciprofloxacin

A 74-year-old woman with multiple medical problems including chronic renal failure was admitted for treatment of a diabetic foot infection. On day 12 of therapy with oral ciprofloxacin and metronidazole, the patient experienced generalized myoclonus and muscle twitching. At that time it was realized that although the ciprofloxacin regimen prescribed was a usual dose for a skin and soft-tissue infection, it was excessive for her degree of renal function. This was thought to be the most likely cause of the patient's neurotoxicity. Seizure activity has been reported to occur with the quinolone antibiotics and, with the increasing use of these agents, dose reductions should be kept in mind to avoid potentially serious adverse reactions.

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				H. Kita, H. Matsuo, H. Takanaga, J. Kawakami, K. Yamamoto, T. Iga, M. Naito, T. Tsuruo, A. Asanuma, K. Yanagisawa, et al. In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System Antimicrob. Agents Chemother., May 1, 1999; 43(5): 1091 - 1097. [Abstract] [Full Text]