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Research Articles |
This case illustrates a severe adverse reaction of the central nervous system involving a moderate overdose of diclofenac sodium along with therapeutic dosages of indomethacin and ibuprofen. Our patient became disoriented, hallucinated, lost consciousness, and suffered respiratory arrest after ingesting five diclofenac tablets (375 mg total), two ibuprofen tablets (400 mg total), and one indomethacin capsule (75 mg). Aggressive supportive therapy was instituted and the patient improved. She was awake, alert, and extubated in less than 24 hours with no serious sequelae.
This article has been cited by other articles:
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  A. L Bernstein and A. Werlin Pseudodementia Associated with Use of Ibuprofen Ann. Pharmacother., January 1, 2003; 37(1): 80 - 82. [Abstract] [Full Text] [PDF]
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 L. Gomez-Lopez, J. Hernandez-Rodriguez, J. Pou, and S. Nogue Acute overdose due to benzydamine Human and Experimental Toxicology, July 1, 1999; 18(7): 471 - 473. [Abstract] [PDF]
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