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DICP, The Annals of Pharmacotherapy: Vol. 25, No. 5, pp. 469-470.
© 1991 Harvey Whitney Books Company.
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Research Articles

Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion

M Kohli-Kumar, AD Pearson, I Sharkey, and AW Craft

Vomiting is one of the most distressing adverse effects of cancer chemotherapy. Metoclopramide by continuous infusion (400 micrograms/kg/h after a loading dose of 2.5 mg/kg) is a novel administration method for optimizing efficacy. A two-year-old boy developed urinary retention on three occasions, once accompanied by priapism and slurred speech, while receiving a continuous infusion. This was reversed by procyclidine, suggesting that it may have been a dystonic reaction.




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Copyright © 1991 by Harvey Whitney Books Company.