The Annals the journal of Pharmacy Technology
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DICP, The Annals of Pharmacotherapy: Vol. 25, No. 5, pp. 471-472.
© 1991 Harvey Whitney Books Company.
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Research Articles

Idioventricular rhythm: hypervagotonia associated with placebo

NR Cutler, AH Heller, NM Kurtz, Sramek JJ Jr, TE Lynch, PP Zolnouni, DK Gandhi, and S Sawin

We report a case of hypervagotonia manifested by idioventricular rhythm in a healthy, athletic man who participated in a Phase I study of an investigational calcium-channel blocker. Upon breaking the study's double-blind study code, it was discovered that the subject had received placebo. We discuss this unusual finding and the implications of including athletic subjects in safety/tolerance studies.


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A. J. Barsky, R. Saintfort, M. P. Rogers, and J. F. Borus
Nonspecific Medication Side Effects and the Nocebo Phenomenon
JAMA, February 6, 2002; 287(5): 622 - 627.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by Harvey Whitney Books Company.