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The Annals of Pharmacotherapy: Vol. 26, No. 11, pp. 1381-1382.
© 1992 Harvey Whitney Books Company.
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Research Articles

Lisinopril-induced "scalded mouth syndrome"

LB Savino and NM Haushalter

OBJECTIVE: To report a case of "scalded mouth syndrome" (SMS) caused by lisinopril. PATIENT: A woman being treated with lisinopril for hypertension developed a burning sensation of her lips and buccal mucosa. The condition persisted with continued use of lisinopril and subsided when the medication was discontinued. CONCLUSIONS: The symptoms described by our patient were similar to those reported in previous cases of SMS associated with the use of enalapril and captopril, two other angiotensin-converting enzyme (ACE) inhibitors. This reaction to ACE inhibitors appears to be dose related, and subsides with a decreased dosage or discontinuation of the medication.


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A. Scala, L. Checchi, M. Montevecchi, I. Marini, and M.A. Giamberardino
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Copyright © 1992 by Harvey Whitney Books Company.