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The Annals of Pharmacotherapy: Vol. 26, No. 2, pp. 211-212.
© 1992 Harvey Whitney Books Company.
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Research Articles

Fluoxetine-induced psoriasis

C Hemlock, JS Rosenthal, and A Winston

BACKGROUND: A number of medications have been reported to induce psoriasis. We report two cases of fluoxetine-related psoriasis and discuss similarities between lithium-, trazodone hydrochloride-, and fluoxetine-induced psoriasis. OBSERVATIONS: Two women being treated for depression with fluoxetine developed psoriasis after 6 and 12 months' exposure. This time frame is clinically similar to that observed with lithium-induced psoriasis. CONCLUSIONS: The occurrence of lithium- and fluoxetine-induced psoriasis may not be random. Both drugs modulate serotonergic function, a factor that may contribute to the pathophysiology of psoriasis. If a patient on acute or long-term fluoxetine therapy develops psoriasis, the drug should be considered as a possible etiologic agent.


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 Am. J. PsychiatryHome page
S. F. OSBORNE, L. STAFFORD, and K. G. D. ORR
Paroxetine-Associated Psoriasis
Am J Psychiatry, December 1, 2002; 159(12): 2113 - 2113.
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Copyright © 1992 by Harvey Whitney Books Company.