The Annals Take our Readership Survey!
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     

The Annals of Pharmacotherapy: Vol. 26, No. 4, pp. 515-519.
© 1992 Harvey Whitney Books Company.
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rindone, J.
Right arrow Articles by Sloane, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rindone, J.
Right arrow Articles by Sloane, E.

Research Articles

Cyanide toxicity from sodium nitroprusside: risks and management

JP Rindone and EP Sloane

OBJECTIVE: To review the risks, manifestations, and treatment of cyanide toxicity from nitroprusside therapy. DATA SOURCES: All English case reports identified in Index Medicus (MEDLINE) of cyanide intoxication related to nitroprusside from 1970 to the present were reviewed. In addition, literature regarding the incidence, risks, and treatment of cyanide toxicity from nitroprusside is presented. CONCLUSIONS: Numerous cases of cyanide toxicity associated with nitroprusside have been reported. The overall incidence appears to be infrequent; however, certain patients may be at high risk. Risk factors may include hypoalbuminemia, cardiopulmonary bypass procedures, or the administration of moderate to high doses of nitroprusside. Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions.


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
A. T. Cheung, G. E. Cruz-Shiavone, Q. C. Meng, A. Pochettino, J. A. Augoustides, J. E. Bavaria, and E. A. Ochroch
Cardiopulmonary Bypass, Hemolysis, and Nitroprusside-Induced Cyanide Production
Anesth. Analg., July 1, 2007; 105(1): 29 - 33.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
D. P. Betten, R. B. Vohra, M. D. Cook, M. J. Matteucci, and R. F. Clark
Antidote use in the critically ill poisoned patient.
J Intensive Care Med, September 1, 2006; 21(5): 255 - 277.
[Abstract] [PDF]

Home page
 CirculationHome page
Part 7.4: Monitoring and Medications
Circulation, December 13, 2005; 112(24_suppl): IV-78 - IV-83.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. R. Hyduke and J. C. Liao
Analysis of nitric oxide donor effectiveness in resistance vessels
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2390 - H2399.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
J. W Devlin, M. L Seta, S. Kanji, and A. L Somerville
Fenoldopam Versus Nitroprusside for the Treatment of Hypertensive Emergency
Ann. Pharmacother., May 1, 2004; 38(5): 755 - 759.
[Abstract] [Full Text] [PDF]


homecopy help contact us subscription past issues search current issue
Copyright © 1992 by Harvey Whitney Books Company.