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The Annals of Pharmacotherapy: Vol. 26, No. 9, pp. 1087-1088.
© 1992 Harvey Whitney Books Company.
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Research Articles

Use of granulocyte colony-stimulating factor in the treatment of pancytopenia secondary to colchicine overdose

R Katz, LC Chuang, and JD Sutton

OBJECTIVE: To report a case of pancytopenia following colchicine overdose and to discuss the use of granulocyte colony-stimulating factor (G-CSF) for treating this severe complication. CASE SUMMARY: A 19-year-old man developed pancytopenia four days after ingestion of approximately 50-60 0.6-mg colchicine tablets in a suicide attempt. His pancytopenia resolved after subcutaneous administration of one 300-micrograms dose of G-CSF. The patient recovered from his other multiorgan disturbances during his hospitalization and was discharged from the hospital with elevated liver enzyme concentrations. CONCLUSIONS: Colchicine overdose is rare, but can be fatal. The use of G-CSF appears to be beneficial in alleviating bone marrow depression in colchicine overdose situations.


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 Hum Exp ToxicolHome page
B. Atas, H. Caksen, O. Tuncer, E. Kirimi, C. Akgun, and D. Odabas
Four children with colchicine poisoning
Human and Experimental Toxicology, July 1, 2004; 23(7): 353 - 356.
[Abstract] [PDF]


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Copyright © 1992 by Harvey Whitney Books Company.