Isoniazid-associated psychosis: case report and review of the literature

OBJECTIVE: To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect. DATA SOURCES: Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information. STUDY SELECTION: All case reports describing isoniazid-associated psychosis were reviewed. DATA EXTRACTION: Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid. DATA SYNTHESIS: The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare. CONCLUSIONS: The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.