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The Annals of Pharmacotherapy: Vol. 27, No. 5, pp. 584-585.
© 1993 Harvey Whitney Books Company.
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Research Articles

Ondansetron in the treatment of intractable nausea associated with theophylline toxicity

TA Sage, WN Jones, and RF Clark

OBJECTIVE: To report the efficacy of ondansetron in the treatment of a patient poisoned with theophylline. PATIENT: A 36-year-old man who ingested 6 g of sustained-release theophylline. INTERVENTION: Ondansetron 8 mg intravenously after clinical failure of other antiemetics. RESULTS: Subjective relief of nausea within minutes, enabling the patient to tolerate multiple doses of activated charcoal and whole bowel irrigation. CONCLUSIONS: Ondansetron may offer an alternative to present antiemetic therapy in the poisoned patient.


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B. Mokhlesi, J. B. Leikin, P. Murray, and T. C. Corbridge
Adult Toxicology in Critical Care: Part II: Specific Poisonings
Chest, March 1, 2003; 123(3): 897 - 922.
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Copyright © 1993 by Harvey Whitney Books Company.