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The Annals of Pharmacotherapy: Vol. 28, No. 5, pp. 587-589.
© 1994 Harvey Whitney Books Company.
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Research Articles

Pleural effusion associated with chronic dantrolene administration

JM Mahoney and MD Bachtel

OBJECTIVE: To report a case of pleural effusion associated with chronic dantrolene administration. DESIGN: Case report. SETTING: Private, university-affiliated, teaching hospital. RESULTS: Twelve years after the initiation of low-dose dantrolene therapy for chronic spasticity, a 35-year-old man developed a pleural effusion with pleural and peripheral eosinophilia. This reaction gradually resolved over several months after discontinuation of the dantrolene therapy. CONCLUSIONS: In patients treated with chronic dantrolene therapy, the presence of pleural effusions should raise the suspicion of dantrolene-induced disease. Withdrawal of dantrolene therapy has generally been associated with an alleviation of signs and symptoms within several months.




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Copyright © 1994 by Harvey Whitney Books Company.