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Research Articles |
The empirical evidence supporting the use of topical NSAIDs in acute soft tissue injuries is weak. However, patient ratings of improvement consistently favor NSAID treatment over placebo. Although it is very difficult to differentiate the placebo effect from the natural course of improvement in these patients, the overall impression given by these studies is that of superior efficacy of topical NSAIDs over placebo. The study by Akermark and Forsskahl suggests that indomethacin applied topically is as effective as therapeutic doses of oral indomethacin. Further studies need to be conducted to generalize this conclusion to other NSAIDs. Studies comparing the relative efficacy of topical NSAIDs with counterirritants available over-the-counter (e.g., menthol, camphor, methylsalicylate) also would be useful.
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  T. Palmer and J. D. Toombs Managing Joint Pain in Primary Care J Am Board Fam Med, November 1, 2004; 17(suppl_1): S32 - S42. [Abstract] [Full Text] [PDF]
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 H G Predel, R Koll, H Pabst, R Dieter, G Gallacchi, B Giannetti, M Bulitta, J L Heidecker, and E A Mueller Diclofenac patch for topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study Br. J. Sports Med., June 1, 2004; 38(3): 318 - 323. [Abstract] [Full Text] [PDF]
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 N. Mcgriff-Lee Management of Acute Soft Tissue Injuries Journal of Pharmacy Practice, February 1, 2003; 16(1): 51 - 58. [Abstract] [PDF]
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 M. PADILLA, G. T. CLARK, and R. L. MERRILL TOPICAL MEDICATIONS FOR OROFACIAL NEUROPATHIC PAIN: A REVIEW J Am Dent Assoc, February 1, 2000; 131(2): 184 - 195. [Abstract] [Full Text] [PDF]
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