Chlorobutanol toxicity

Although chlorobutanol is available in a large number of preparations, the incidence of toxicity appears to be low. However, with continued exposure to high-dose chlorobutanol, significant toxicity may occur. It seems prudent to use caution in the continued administration of products containing chlorobutanol. The lack of pharmacokinetic data warrant that extra care be used when administering chlorobutanol-containing products to patients with hepatic or renal dysfunction. Patients should be monitored for possible increased somnolence, alterations in speech pattern, dysarthria, and hemodynamic changes. Chlorobutanol toxicity should be ruled out by serum analysis if the patient exhibits any of the above reactions.