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Research Articles |
OBJECTIVE: To report a case of symptomatic cardiomyopathy induced during treatment with clozapine, an antipsychotic of the dibenzodiazepine class. CASE SUMMARY: A patient with a long psychiatric history significant for schizophrenia and no prior cardiac history developed dyspnea, malaise, and edema with a low ventricular ejection fraction during clozapine therapy. DISCUSSION: The literature concerning cardiorespiratory complications with clozapine therapy is reviewed. CONCLUSIONS: Cardiorespiratory complications associated with clozapine use are rare. Caution may be warranted in patients treated with other medications, such as benzodiazepines, and in patients with underlying cardiac disease.
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C. A. Pastor and M. Mehta Masked Clozapine-induced Cardiomyopathy J Am Board Fam Med, January 1, 2008; 21(1): 70 - 74. [Abstract] [Full Text] [PDF] |
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C. M. Amabile and A. P. Spencer Keeping Your Patient With Heart Failure Safe: A Review of Potentially Dangerous Medications Arch Intern Med, April 12, 2004; 164(7): 709 - 720. [Full Text] [PDF] |
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K. L. D. Phan and S. F. Taylor Clozapine-Associated Cardiomyopathy Psychosomatics, June 1, 2002; 43(3): 248 - 248. [Full Text] [PDF] |
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