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The Annals of Pharmacotherapy: Vol. 30, No. 6, pp. 603-605.
© 1996 Harvey Whitney Books Company.
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Research Articles

Cardiomyopathy associated with clozapine

RJ Leo, JL Kreeger, and KY Kim

OBJECTIVE: To report a case of symptomatic cardiomyopathy induced during treatment with clozapine, an antipsychotic of the dibenzodiazepine class. CASE SUMMARY: A patient with a long psychiatric history significant for schizophrenia and no prior cardiac history developed dyspnea, malaise, and edema with a low ventricular ejection fraction during clozapine therapy. DISCUSSION: The literature concerning cardiorespiratory complications with clozapine therapy is reviewed. CONCLUSIONS: Cardiorespiratory complications associated with clozapine use are rare. Caution may be warranted in patients treated with other medications, such as benzodiazepines, and in patients with underlying cardiac disease.


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Copyright © 1996 by Harvey Whitney Books Company.