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The Annals of Pharmacotherapy: Vol. 31, No. 7, pp. 873-875.
© 1997 Harvey Whitney Books Company.
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Research Articles

Paclitaxel formulation as a cause of ethanol intoxication

DB Wilson, TM Beck, and CA Gundlach

OBJECTIVE: To report a case of ethyl alcohol intoxication associated with paclitaxel administration. CASE SUMMARY: A patient who received a 3-hour paclitaxel infusion for metastatic breast carcinoma and developed symptoms of acute alcohol intoxication. A blood ethanol concentration drawn at the end of the paclitaxel infusion was 97.8 mg/dL (0.098%). DISCUSSION: The amount of alcohol contained in paclitaxel is discussed. A review of the literature revealed one patient series where the highest blood alcohol concentration was one-third that seen in our patient. CONCLUSIONS: Clinicians should recognize the potential for alcohol intoxication with paclitaxel administration. This is especially pertinent when higher doses are given over a short period of time.




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Copyright © 1997 by Harvey Whitney Books Company.