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Research Articles |
OBJECTIVE: To describe a case of skin ulcer related to methotrexate toxicity. CASE SUMMARY: A 67-year-old white man with seronegative arthralgia developed recurrent skin ulcer concurrent with 3-year treatment with methotrexate 5 mg daily. The skin ulcer resolved on discontinuation of methotrexate. DISCUSSION: To the best of our knowledge, this is the first reported case of skin ulcer believed to be induced by methotrexate in a patient without psoriasis. CONCLUSIONS: Skin ulceration should be added to the list of possible toxic adverse effects of methotrexate, not only in psoriatic patients but also in those without psoriasis.
This article has been cited by other articles:
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  N Hocaoglu, R Atilla, F Onen, and Y Tuncok Early-onset pancytopenia and skin ulcer following low-dose methotrexate therapy Human and Experimental Toxicology, July 1, 2008; 27(7): 585 - 589. [Abstract] [PDF]
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