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Research Articles |
OBJECTIVE: To evaluate the use and potential benefit of famotidine in the management of schizophrenia. DATA SOURCES: Clinical literature accessed through MEDLINE (February 1998-October 1998). Key search terms included famotidine, schizophrenia, and histamine. DATA SYNTHESIS: Schizophrenia is a complicated disorder associated with high morbidity if left unmanaged. Histamine2 (H2)-antagonists may be an alternative to conventional treatments. An evaluation of studies focusing on famotidine in the management of schizophrenic symptoms was conducted. CONCLUSIONS: Famotidine can improve schizophrenic symptoms that were otherwise refractory to typical antipsychotic agents. Further studies should be conducted to determine if other H2-antagonists are also effective.
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  H. L. Haas, O. A. Sergeeva, and O. Selbach Histamine in the Nervous System Physiol Rev, July 1, 2008; 88(3): 1183 - 1241. [Abstract] [Full Text] [PDF]
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