Levofloxacin-induced bilateral Achilles tendonitis

OBJECTIVE: To report a case of possible levofloxacin-induced bilateral Achilles tendonitis. CASE SUMMARY: An 83-year-old white woman presented to her physician with five days of hemoptysis. She was diagnosed with right lower-lobe pneumonia based on chest X-ray, and levofloxacin 500 mg/d po for 10 days was prescribed. Three days into treatment she began having a variety of adverse effects, including severe nausea, constipation, stomach cramps, and dizziness. Signs of tendonitis began three days after treatment and peaked four days after completion of therapy. Two weeks later, she was treated by her podiatrist with an ankle immobilizer and rest. At her three-week follow-up, she had marked improvement in her pain and bruising; however, her symptoms had not completely resolved. DISCUSSION: Tendonitis and tendon rupture are rare adverse effects of fluoroquinolone antibiotics; there are no reports in the literature of levofloxacin-induced tendonitis. As newer fluoroquinolones become available, the postmarketing studies will become increasingly important to capture the data on rare but serious adverse effects not discovered in the premarketing trials. CONCLUSIONS: To our knowledge, this is the first reported case of tendonitis caused by levofloxacin reported in the literature. Reports have been made, however, to the manufacturer via postmarketing surveillance. As more people are treated with newer fluoroquinolones, the clinical incidence of tendon rupture with these agents may become clearer.

This article has been cited by other articles:

				F. Pouzaud, K. Bernard-Beaubois, M. Thevenin, J.-M. Warnet, G. Hayem, and P. Rat In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress J. Pharmacol. Exp. Ther., January 1, 2004; 308(1): 394 - 402. [Abstract] [Full Text] [PDF]

				A S. Mathis, V. Chan, M. Gryszkiewicz, R. T Adamson, and G. S Friedman Levofloxacin-Associated Achilles Tendon Rupture Ann. Pharmacother., July 1, 2003; 37(7): 1014 - 1017. [Abstract] [Full Text] [PDF]

				L. J. Haddow, M. Chandra Sekhar, V. Hajela, and G. Gopal Rao Spontaneous Achilles tendon rupture in patients treated with levofloxacin J. Antimicrob. Chemother., March 1, 2003; 51(3): 747 - 748. [Full Text] [PDF]