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The Annals of Pharmacotherapy: Vol. 33, No. 9, pp. 957-959. DOI 10.1345/aph.18359
© 1999 Harvey Whitney Books Company.
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Research Articles

Propafenone disposition during continuous venovenous hemofiltration

W Seto, AE Trope, and RM Gow

OBJECTIVE: To determine the extent of removal of propafenone by continuous venovenous hemofiltration (CVVH) in a critically ill pediatric patient. CASE SUMMARY: A three-year-old white-Japanese girl was admitted to the critical care unit following cardiac surgery. Her postoperative course was complicated by the development of junctional ectopic tachycardia, requiring propafenone, and acute renal failure, which necessitated the use of CVVH. The serum and ultrafiltrate concentrations of propafenone and its 5-hydroxy metabolite were measured to determine both total and CVVH clearance. CONCLUSIONS: The data from this case report showed that propafenone was not significantly removed by CVVH. Furthermore, the total clearance of propafenone was not affected by the patient's renal or liver function impairment.




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Copyright © 1999 by Harvey Whitney Books Company.