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Research Articles |
OBJECTIVE: To summarize published data on the comparative efficacy of sorbitol and xylitol for prevention of dental caries. DATA SOURCES: Published double-blind comparative trials, using sorbitol and xylitol products, identified by MEDLINE (January 1966-December 1998) and International Pharmaceutical Abstracts (January 1970-December 1998) searches. DATA SYNTHESIS: Clinical trials generally used sorbitol and xylitol gums, which patients chewed three to five times daily for 20-40 months. Xylitol was superior to sorbitol in two longer, secondary dentition trials (30-63% reductions), but not in two primary dentition trials. CONCLUSIONS: The data suggest that xylitol-containing gums may provide superior efficacy in reducing caries rates in high-risk populations.
This article has been cited by other articles:
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  B. A. Burt The use of sorbitol- and xylitol-sweetened chewing gum in caries control J Am Dent Assoc, February 1, 2006; 137(2): 190 - 196. [Abstract] [Full Text] [PDF]
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 T. Tapiainen, T. Kontiokari, L. Sammalkivi, I. Ikäheimo, M. Koskela, and M. Uhari Effect of Xylitol on Growth of Streptococcus pneumoniae in the Presence of Fructose and Sorbitol Antimicrob. Agents Chemother., January 1, 2001; 45(1): 166 - 169. [Abstract] [Full Text]
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