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The Annals of Pharmacotherapy: Vol. 34, No. 3, pp. 382-385. DOI 10.1345/aph.19150
© 2000 Harvey Whitney Books Company.
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Research Articles

Levodopa therapy and the risk of malignant melanoma

JF Siple, DC Schneider, WA Wanlass, and BK Rosenblatt

OBJECTIVE: To evaluate the use of levodopa therapy in patients with Parkinson's disease and malignant melanoma. DATA SOURCES: A MEDLINE search (January 1966-September 1999) of English-language articles was conducted. Key search terms included levodopa, melanoma, and Parkinson's disease; 34 case reports were identified. DATA SYNTHESIS: Carbidopa/levodopa continues to be a mainstay in the treatment of Parkinson's disease. Since the late 1970s, a warning has appeared in the prescribing literature for levodopa regarding the risk of activating malignant melanoma. An evaluation was conducted of the case reports in which a causal relationship between levodopa and melanoma was suggested. CONCLUSIONS: There is an unlikely association between levodopa and induction or exacerbation of malignant melanoma.


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R. Inzelberg and J. Jankovic
Are Parkinson disease patients protected from some but not all cancers?
Neurology, October 9, 2007; 69(15): 1542 - 1550.
[Abstract] [Full Text] [PDF]


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