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Research Articles |
OBJECTIVE: To review the efficacy and safety of inhaled furosemide in the treatment of acute respiratory distress and possible bronchopulmonary dysplasia (BPD) in preterm neonates receiving ventilator and oxygen support. DATA SOURCES: A MEDLINE search was performed from January 1966 to December 1998 using the key words inhaled or aerosolized furosemide, BPD, preterm, neonate, and infant newborn. STUDY SELECTION AND DATA EXTRACTION: All clinical trials involving the use of inhaled furosemide in ventilator- and oxygen-dependent preterm neonates with acute respiratory distress and possible BPD were evaluated. DATA SYNTHESIS: Inhaled furosemide 1 and 2 mg/kg has improved pulmonary function in preterm neonates without significant adverse effects. However, only a single dose of inhaled furosemide was used in these trials, and pulmonary functions were monitored for only two or four hours after administration. CONCLUSIONS: Inhaled furosemide may be effective, but studies are needed to determine the optimal dosage regimen and long-term risks and benefits of its use in these patients.
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  C. J. McMahon, D. J. Penny, D. P. Nelson, A. M. Ades, S. Al Maskary, M. Speer, J. Katkin, E. D. McKenzie, C. D. Fraser Jr, MD, and A. C. Chang Preterm Infants With Congenital Heart Disease and Bronchopulmonary Dysplasia: Postoperative Course and Outcome After Cardiac Surgery Pediatrics, August 1, 2005; 116(2): 423 - 430. [Abstract] [Full Text] [PDF]
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 Statement on the Care of the Child with Chronic Lung Disease of Infancy and Childhood Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 356 - 396. [Full Text] [PDF]
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