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The Annals of Pharmacotherapy: Vol. 34, No. 4, pp. 529-532. DOI 10.1345/aph.19145
© 2000 Harvey Whitney Books Company.
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Research Articles

Management of complications of bacillus Calmette-Guerin immunotherapy in the treatment of bladder cancer

TC Huang

OBJECTIVE: To evaluate the management strategies available for the complications associated with bacillus Calmette-Guerin (BCG) immunotherapy in the treatment of bladder cancer. DATA SOURCES: Clinical literature accessed through MEDLINE (January 1983-January 1999). Key search terms included bacillus Calmette-Guerin, BCG, and bladder cancer. DATA SYNTHESIS: BCG vaccine is a live-attenuated strain of Mycobacterium bovis; therefore, the risk for complications exists. An evaluation of treatment regimens was conducted, and the management strategies are presented. CONCLUSIONS: The complications associated with BCG immunotherapy range from local reactions to potentially fatal systemic reactions requiring long-term therapy. Therefore, healthcare practitioners need to be aware of the current treatment regimens available.




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Copyright © 2000 by Harvey Whitney Books Company.