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Research Articles |
OBJECTIVE: To evaluate the antioxidant effects of acetaminophen in atherosclerosis. DATA SOURCES: Experimental literature and abstracts accessed through MEDLINE (1966-February 2001). DATA SYNTHESIS: Atherosclerosis is an inflammatory disorder associated with coronary events. The oxidative stress burden resulting from excess pro-oxidant free radical formation contributes to oxidative modification of low-density lipoprotein (lipid peroxidation) and is associated with atherosclerosis. Acetaminophen (phenol-like compound) may limit these key processes that are involved. The findings of earlier experimental laboratory tests and abstracts are evaluated. CONCLUSIONS: In vitro data suggest that acetaminophen may reduce lipid peroxidation, whereas animal data showed decreased progression of atherosclerosis. Further animal model and human studies are required to confirm these earlier findings.
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  R. Golfetti, K. VanDyke, T. Rork, N. Spiler, and G. Merrill Acetaminophen in the Post-ischemia Reperfused Myocardium Experimental Biology and Medicine, December 1, 2002; 227(11): 1031 - 1037. [Abstract] [Full Text]
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