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Research Articles |
OBJECTIVE: To report a case involving a witnessed seizure in a patient receiving concurrent olanzapine and quetiapine. CASE SUMMARY: A 27-year-old white woman was observed to have a seizure while receiving a stable dosage of olanzapine 15 mg/d, with the addition of quetiapine 100 mg in the evening 1 day before the occurrence of the seizure. There were no known risk factors for epilepsy. DISCUSSION: This case reports a new-onset seizure in the context of concurrent olanzapine and quetiapine use. Interpretation is complicated by recent discontinuation of low-dose clonazepam. CONCLUSIONS: While uncommon, seizures can occur with non-clozapine atypical antipsychotics. Caution is indicated when using these drugs with other agents that may lower the seizure threshold.
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  U. Lang, M. Willbring, R. von Golitschek, A. Schmeisser, K. Matschke, and S M. Tugtekin Clozapine-induced myocarditis after long-term treatment: case presentation and clinical perspectives J Psychopharmacol, July 1, 2008; 22(5): 576 - 580. [Abstract] [PDF]
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J. Chan and M. Sweeting Review: Combination therapy with non-clozapine atypical antipsychotic medication: a review of current evidence J Psychopharmacol, August 1, 2007; 21(6): 657 - 664. [Abstract] [PDF]
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 O. Dogu, S. Sevim, and H. S Kaleagasi Seizures Associated with Quetiapine Treatment Ann. Pharmacother., September 1, 2003; 37(9): 1224 - 1227. [Abstract] [Full Text] [PDF]
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R. M Bonelli Olanzapine-associated seizure Ann. Pharmacother., January 1, 2003; 37(1): 149 - 150. [Full Text] [PDF]
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